The proteomics profile of tumor-associated macrophages (TAM) indicated that Cat Eye Syndrome Critical Region Protein 1 (CECR1) can promote differentiation of M2 TAMs and affects the proliferation and migration of glioma cells, and 67 proteins are upregulated by CECR1 siRNA transfection in THP-1-derived macrophages (MQs) (92). The gene discussed is ADA2; the disease is central nervous system cancer.