As similar or even identical immune tolerance checkpoint mechanisms have been identified across immune-mediated diseases (202, 203), the co-administration of the self-antigen myelin oligodendrocyte glycoprotein (MOG) together with high doses of CpG-ODN could potentially reduce the autoimmune reaction observed in the experimental autoimmune encephalomyelitis (EAE) mouse model, setting the basis for an antigen-specific tolerance induction therapy in MS and other autoimmune diseases. This evidence concerns the gene MOG and experimental autoimmune encephalomyelitis.