In the studies presented here, we first performed RNA expression analysis on macrophages from whole body MK2 KO mice to explore the molecular mechanisms underlying defective angiogenesis, since we had shown previously that these animals had defective colon tumor angiogenesis, and that macrophages derived from these animals in vitro were less efficient at polarizing into an M2 pro-angiogenic phenotype (25). The gene discussed is MAPKAPK2; the disease is colonic neoplasm.