Our results implicating a critical role for MK2 activity in macrophages for inflammatory colon tumor angiogenesis, however, contrast with those of Henriques et al, who concluded that mesenchymal activity of the MK2/Hsp27 axis exclusively contributes to tumor neo-angiogenesis in a APCmin intestinal tumorigenesis model. The gene discussed is MAPKAPK2; the disease is colonic neoplasm.