MAPKAPK2 and colonic neoplasm: Importantly, although we had previously shown that myeloid-specific MK2 KO animals fully recapitulated the colon tumor angiogenesis-defective phenotype seen in whole body MK2 KO mice (25), it was possible that the defective tumor angiogenesis phenotype seen in the myeloid MK2 KO resulted from MK2 signaling in non-macrophage myeloid cell types such as neutrophils or dendritic cells.