Both global and myeloid-specific MK2 knock-outs, as well as bulk macrophage depletion results in similar numbers of tumors but a significant reduction in tumor size, as well as a reduction in the presence CD31+ endothelial cells within the tumors consistent with impaired tumor angiogenesis and progression [Figure 3 and (25)]. The gene discussed is MAPKAPK2; the disease is neoplasm.