We had previously shown that myeloid-specific depletion of MK2 results in smaller tumors in the AOM/DSS model, with less infiltration of M2 macrophages and reduced vascularization [Supplemental Figure 2, (25)] recapitulating the phenotype observed in the whole-body KO (25) and by macrophage depletion in this tumor model (Figures 3B–D). The gene discussed is MAPKAPK2; the disease is infectious otitis media.