While our experiments cannot completely rule out some contribution of the mesenchymal MK2/Hsp27 axis to tumor angiogenesis as proposed by Henriques et al., the data presented here strongly implicate the importance of macrophages in regulating angiogenesis in the AOM/DSS colon cancer model, which is consistent with a widely recognized role of macrophages in regulating tumor angiogenesis is a variety of cancer types (83, 84). Here, MAPKAPK2 is linked to colonic neoplasm.