INS and fatty liver disease: What’s more, we found that RSV can affect the insulin signaling pathway and the changes is associated with altered gut microbiota, previous findings showed that changes in the insulin signaling pathway can affect liver steatosis by altering the lipid metabolism process (Leavens and Birnbaum, 2011; Smith et al., 2020), suggesting that RSV may also reduce fatty acid metabolism genes by improving the insulin signaling pathway.