In conclusion, despite more detailed mechanisms needed to be determined, our findings not merely reveal a novel action with its possible mechanism of ginsenoside Rc which effectively ameliorated endothelial IR and endothelial dysfunction, at least in part, via upregulation of ACE2 but also provide new insight into the potential clinical application of ginsenoside Rc which holds promise for the treatment of diabetic vascular complications. The gene discussed is ACE2; the disease is endothelial dysfunction.