Although Ang-(1–7) has been reported to improve endothelial dysfunction in db/db mice and Ang II-induced IR in endothelial cells (Tassone et al., 2013; Zhang et al., 2015), literature about ACE2/Ang-(1–7)/Mas axis emphasizing endothelial IR remains scarce. This evidence concerns the gene MAS1 and endothelial dysfunction.