Considering the well-established role of inflammation and oxidative stress in IR (Kim et al., 2006; McNelis and Olefsky, 2014) as well as the essential part played by ACE2/Ang-(1–7)/Mas axis in cardiovascular complications (Jiang et al., 2014; Patel et al., 2014), we wondered whether ginsenoside Rc could contribute to the alleviation of endothelial IR and endothelial dysfunction via activating ACE2/Ang-(1–7)/Mas axis. This evidence concerns the gene ACE2 and endothelial dysfunction.