Experiment has shown that CoVs play a destructive role in acute disseminated encephalomyelitis (ADEM) correlated with increased inflammatory mediators such as IL-6, IFN-γ, TNF-α, CXCL9, and CXCL10 (Kothur et al., 2016). This evidence concerns the gene IFNG and acute disseminated encephalomyelitis.