Naringin also inhibits the expression level of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), IL-1β and IL-6 via suppressing high mobility group box 1 (HMGB1) in COVID-19 (Park et al., 2003; Huang et al., 2020a). The gene discussed is HMGB1; the disease is COVID-19.