Additionally, several lines of evidence indicated that asiaticoside (a saponin), borneol (a terpene), catalpol (an iridoid) as other phytochemicals declined the neuronal levels of TNF-α, IL-6, TLR4, NF-κB, IL-β and IL-8, thus may be hopeful agents against neurological symptoms in COVID-19 (Welcome, 2020). This evidence concerns the gene TNF and COVID-19.