ACE2 and COVID-19: In addition to the critical role of blood, hypoxia, ACE2, neuroinflammation in the neuronal pathogenesis of COVID-19, modulating RdRP/3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro), as critical enzymes involved in the replication of SARS-CoV-2, is of great importance.