TNF and COVID-19: As a major natural derivative of resveratrol, polydatin potentially decline the neural levels of NF-κB, TNF-α, IL-1β, IL-6, IL-8, prostaglandin E2 (PGE2), NO, COX-2, iNOS, matrix metalloproteinase (MMP)-3 and MMP-9, thereby could be a novel agents in combating neuronal inflammatory manifestation in COVID-19 (Lo Muzio et al., 2020).