TSPO and early-onset autosomal dominant Alzheimer disease: Previous studies have found that the expression of TSPO is significantly increased when the nervous system is damaged, especially in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis (Turner et al., 2004; Ghadery et al., 2017; Simmons et al., 2018; Gui et al., 2020).