ACE2 and Hypertension: In light of the above data in diabetic mice and patients (Mizuiri et al., 2011; Gutta et al., 2018), we hypothesized that kidney injury and hypertension in the 2K1C Goldblatt model could also increase the shedding of ACE2 and NEP into the urine, and deleting AT1R will attenuate this effect.