Next, we examined the indexes of urine Ca2+ and P4+, serum Ca2+, P4+, ALP, VD3, FGF23 and iPTH, as well as TBBMD, FBBMD and pathological lesions of the femur bone in the sham-operated rats and the CKD–MBD model rats. Here, FGF23 is linked to chronic kidney disease.