After the treatment of FPS or CTR for 3 weeks, in addition to serum FGF23 and BMD, the levels of urine Ca2+, P4+, serum Ca2+, P4+ and VD3 in the CKD–MBD model rats were ameliorated significantly, compared to those of the CKD–MBD group rats (Figures 3A–E and Figures 4A,B). The gene discussed is FGF23; the disease is chronic kidney disease.