FGF23 and bone disorder: In the clinic, chronic kidney disease (CKD) patients with renal dysfunction often suffer from disturbances in mineral and bone disorder including metabolic dysregulation of calcium (Ca2+), phosphorus (P4+), parathyroid hormone, vitamin D and fibroblast growth factor 23 (FGF23), that ultimately causes ectopic calcification in vasculature and bone abnormality (Hruska et al., 2017).