Also as shown in Table 1, significant changes of urine Ca2+ and P4+, serum Ca2+, P4+, ALP, VD3, FGF23 and iPTH, as well as obvious decline in TBBMD and FBBMD were found in the CKD–MBD model rats, respectively, compared to those of the sham-operated rats. Here, FGF23 is linked to Marchiafava-Bignami disease.