With the good safety profile of eugenol and its ability to downregulate key pro-inflammatory cytokines like IL-6 and TNFα consequently reducing leukocyte recruitment in lung tissue, it can be a suitable natural immunosuppressant that can be used as an adjuvant along with antiviral agents to suppress the hypercytokinemia and hyperinflammation observed in COVID-19. Here, IL6 is linked to COVID-19.