Nuclear factor-kB (NF-κB) activated signaling pathway have been linked with proliferation, angiogenesis, invasion and metastasis in many tumors including breast cancer, prostate cancer and HCC (Sung et al., 2008; Liu et al., 2015; Ren et al., 2017; Wang et al., 2018). Here, NFKB1 is linked to Familial prostate cancer.