Finnaly, we found that SA downregulated protein levels of metastasis-related DEGs, including KRT7, SERPINE2, DKK1, KRT81, and confirmed that the downregulation of KRT7 and KRT81 could inhibit HCC metastasis by employing siRNA-mediated downregulation of KRT7 and KRT81. The gene discussed is KRT81; the disease is hepatocellular carcinoma.