HCRTR2 and cocaine dependence: In parallel, to further understand whether a history of cocaine dependence affects the Orx system and thus explain the reinstating effect of OrxA when injected in the pPVT at intermediate abstinence vs. protracted abstinence, we analyzed the number of Orx+ cells in the LH, DMH, and PFA and the number of OrxR1+ and OrxR2+ cells in the pPVT.