NFE2L2 and Friedreich ataxia: As NRF2 regulates many genes directly involved in counteracting oxidative stress and NRF2 signaling axis is defective in FRDA (Paupe et al., 2009; Cuadrado et al., 2019; Petrillo et al., 2019), the evaluation of NRF2 expression in this family can help to open a window on new protective factors potentially buffering the FRDA symptomatology.