SOD1 and amyotrophic lateral sclerosis: Overall, enrichment analyses in SOD1-G93A (ALS) mice highlight immune and neuronal-related modules as key disrupted pathways in the spinal cord and implicates the dysregulation of SC.M2, a module enriched with ALS genetic risk, and SC.M6, a module enriched with ALS genetic modifiers, in later stages of disease progression (Fig. 5E).