High-density SNP array and whole exome sequencing analyses showed no evidence of inactivating NF1 mutations in either 2XSB cells or their parent tumor and we demonstrated that 2XSB cells expressed functional full-length neurofibromin protein, indicating that 2XSB cells are derived from the subset of sporadic MPNSTs that have intact NF1. As the pathogenesis of NF1-intact sporadic MPNSTs is poorly understood, the 2XSB cell line represents a valuable tool for investigating the mechanisms underlying the pathogenesis of neurofibromin-expressing sporadic MPNSTs. The gene discussed is NF1; the disease is neoplasm.