EZH2 and neoplasm: We also observed copy number gains in EZH2 (chr7:148,504,464–148,581,441), PTEN (with LOH, chr10:89,622,870–89,731,687), and EED (chr11:85,955,806–85,989,785) in both the cell line and tumor (Supplementary Table 1) Like NF1, the tumor suppressor CDKN2A is frequently mutated in NF1-associated MPNSTs.