After performing several molecular analyses, including 13 multiplex RT-PCRs, NGS using the kinome kit, and IGH capturing, only five patients with childhood B-ALL were identified with non-Ph kinase fusions, which comprised EBF1-PDGFRB, ETV6-ABL1, ZC3HAV1-ABL2, EPOR-IGH and the novel CNTRL-ABL1. The gene discussed is EBF1; the disease is precursor B-cell acute lymphoblastic leukemia.