TNFAIP8 and skin cancer: Normal HaCaT cells, A431, A375, A2058 cells expressed isoform one, whereas expression of isoform one is not observed in SK-MEL-2 cells suggesting that, skin cancer cells expressed isoform two predominantly (Fig. 2B) and the involvement of TNFAIP8 variant/isoform 2 in lung cancer and liver cancer development and progression has been reported earlier37,43.