The data suggest that induction of TNFAIP8 by TNFα (10–20 ng/ml) increased cell survival in normal HaCaT cells as well as in A431 cells and A375, A2058 melanoma cell lines significantly, whereas, a higher concentration of TNFα (50 ng/ml) treatment decreased cell survival in A431, A375 and A2058 skin cancer cell lines (Fig. 2E). This evidence concerns the gene TNFAIP8 and melanoma.