Since NF-κB regulates the expression of TNFAIP8, the exact role of B-RAFV600E mutant in the regulation of TNFAIP8 expression transcriptionally or post-transcriptionally through NF-κB is not clear, however, our data suggest that mutant B-RAFV600E downregulates the expression of TNFAIP8 (mRNA) as well as decreases the level/stability of TNFAIP8 protein in A375 and A2058 melanoma cells. Here, TNFAIP8 is linked to melanoma.