Since disruption of the p53 pathway was reported in melanoma14, and recently the role of TNFAIP8 in p53 signaling was analyzed in lung cancer cells and the study revealed that TNFAIP8 variant 2 (v2) represses tumor suppressor wild-type p53 function in lung cancer A549 cells37. The gene discussed is TNFAIP8; the disease is lung cancer.