To establish the role of TNFAIP8 in skin cancer, we compared the expression of TNFAIP8 in normal human skin cell line HaCaT (B-RAF wild) to human skin cancer cell lines, including the epidermoid squamous cell carcinoma A431 (B-RAF wild) and melanoma cell lines A375, A2058 (B-RAFV600E mutant) and SK-MEL-2 (B-RAF wild) cells. The gene discussed is TNFAIP8; the disease is skin cancer.