B-RAFV600E mutant protein is constitutively active51 and earlier studies demonstrated that B-RAFV600E mutant dysregulates NF-κB/Snail/RKIP/PTEN circuit as well as activates MEK/ERK kinases that promote the epithelial to mesenchymal transition (EMT) and melanoma cell growth51,52. This evidence concerns the gene NFKB1 and melanoma.