Our data suggest that treatment of TNFα (20 ng/ml) increased TNFAIP8 expression and cell survival after 12–24 h and significantly decreased the TNFAIP8 expression and cell survival after 48 h treatment (Supplementary Fig. S1A,B) suggesting that, TNFα regulates the expression of TNFAIP8 and cell survival in skin cancer cells with a time-dependent manner. This evidence concerns the gene TNFAIP8 and skin neoplasm.