Previously, we showed that TNFAIP8 mediated induction of autophagy is required for drug resistance and cell survival in prostate cancer cells34 as well as liver cancer cells43, and similarly, in the current study we demonstrated that miR-205-5p controls the expression of TNFAIP8 and TNFAIP8 mediated-autophagy in skin cancer cells. Here, TNFAIP8 is linked to skin neoplasm.