Consistent with earlier reports, immunoblotting data from our laboratory indicate that all the skin cancer cell lines and normal skin cells used in this study expressed moderate levels of either B-RAF wild-type protein in HaCaT, A431, SK-MEL-2 cells, or B-RAFV600E mutant protein in A375 and A2058 cells (Fig. 1D)49,50. The gene discussed is BRAF; the disease is skin neoplasm.