BECN1 and retinal ischemia: On the other hand, studies that have used retinal ischemia/reperfusion models, which are characterized by an acute elevation of IOP by pressurizing the anterior chamber, have reported a decrease in LC3-II and Beclin-1 level, as early as at 1 h after the insult, which then returned to normal levels after 6 to 24 h39,40.