We identified nonsynonymous SNVs in tumor tissues, such as SMARCA4 (in 192D0360T and 192D0641T), BCOR and LRP1B in 192D0641T, as well as frameshift mutations of KMT2D in 192D0695T and truncating mutations of PTCH1 in 192D0583T. The gene discussed is LRP1B; the disease is neoplasm.