Tumor type-specific deviations from the primary ACE2/TMPRSS2 cluster were observed for prostate (r = − 0.05, m = 0.06) and GI cancers (r = 0.27, m = 0.35), while expression in NSCLC tumors (r = 0.07, m = 0.46) largely overlapped with the primary cluster. Here, TMPRSS2 is linked to neoplasm.