Tight-junction protein at the blood–brain barrier, claudin-5 (Cldn5, brown, cytoplasmic), was reduced in the tumor core (P = 4.65 × 10–6), Supplementary Fig. S2, and elevated endothelial cell marker, erythroblast-transformation-specific related gene (ERG, magenta, nuclear), detected hypervascularity within infiltrating tumor beds (P = 2.73 × 10–7). The gene discussed is ERG; the disease is neoplasm.