Interestingly, we found that VSV and SeV infections, but not other treatments including HBV, HSV, and poly(dA:dT) and poly(I:C), robustly enhanced cytoplasmic translocation of METTL3 from nucleus (Fig. 3b–d and Supplementary Fig. 4b), while the nuclear membranes were intact determined by Lamin A/C staining (Fig. 3c), demonstrating that the translocation of METTL3 in the cell was a natural phenomenon in response to infection rather than resulted from the breach of the nuclear membrane. Here, METTL3 is linked to infection.