Specifically, analyses of the Cancer Therapeutics Response Portal (CTRP)27–29 revealed that FSP1 (also known as AIFM2) exhibited the most striking positive correlation with resistance to multiple class 2 FINs that inactivate GPX4, including RSL3, ML162, and ML210 (Supplementary Fig. 3a), which is consistent with recent reports that FSP1 acts in parallel to GPX4 to inhibit ferroptosis30,31. The gene discussed is GPX4; the disease is cancer.