In addition to the neurological phenotype, Asc-1 knockout mice show a complex metabolic phenotype with reduced body size and weight, hepatosteatosis, hypoglycemia, and reduced body temperature (Supplementary Fig. 2b–f), the latter most likely due to a strong decrease in Ucp1 expression in brown fat (Supplementary Fig. 2h). This evidence concerns the gene UCP1 and Hypoglycemia.