CD4 and peeling skin syndrome: A253 cells pretreated with H. parainfluenzae at the ratio of 100:1 of bacteria-to-cell, significantly suppressed the proliferation of CD4 T cells isolated either from healthy donors (mean ± SD: 56.8 ± 4.0%, 49.7 ± 0.5%, and 18.5 ± 3.3% in control, 10:1, and 100:1 respectively; one-way ANOVA, p < 0.001 and post hoc analysis, p < 0.001 in control and 10:1 versus 100:1; Fig. 5a), or from pSS patients (mean ± SD: 90.8 ± 4.0%, 87.7 ± 2.5%, and 12.5 ± 3.3% in control, 10:1, and 100:1 respectively; one-way ANOVA, p < 0.001 and post hoc analysis, p < 0.001 in control and 10:1 versus 100:1; Fig. 5a).