ERBIN and neoplasm: When we co-cultured B cells of cKO mice with CD8+ T cells wild-type mouse and tumor cells, the effects of killing tumor cells were close to the effect of co-culturing B cells and CD8+ T cells both from cKO mouse, with tumor cells (Fig. 6m), further supporting the key regulatory effects of Erbin-deficient B cells in the function of CD8+ T cells in killing tumor cells.