PTPRC and colorectal carcinoma: To test the effects of targeting Erbin in mouse model of lung metastasis of CRC, we used in vivo siRNA system targeting Erbin (Fig. S5) and/or combination with multiple neutralizing antibodies including anti-CD19 and anti-B220 antibodies, neutralizing PD1 antibodies, and siRNAs targeting the Erbin gene to analyze their simple or combined effects on lung metastasis of CRC (Fig. 8a).