Erbin, an adaptor for the receptor Erbb2/Her2,2,30 plays the key role in cancer progression in many types of cancer including breast cancer, colon cancer, and liver cancer.31–33 Interestingly, a recent study reported that Erbin mutation in tumor cells triggered effective immune responses from a colon cancer patient with lung metastasis.34 Nevertheless, the role of Erbin in the tumor microenvironment was still unclear. This evidence concerns the gene ERBB2 and liver cancer.