To test the effects of targeting Erbin in mouse model of lung metastasis of CRC, we used in vivo siRNA system targeting Erbin (Fig. S5) and/or combination with multiple neutralizing antibodies including anti-CD19 and anti-B220 antibodies, neutralizing PD1 antibodies, and siRNAs targeting the Erbin gene to analyze their simple or combined effects on lung metastasis of CRC (Fig. 8a). Here, ERBIN is linked to colorectal carcinoma.