We detected different subpopulations of mature B in the lung metastasis of CRC in both Erbin full knockout and B-cell cKO mice and found that the number of plasma cells infiltrating in the lung metastases of CRC was significantly elevated for about 3–10 times in the two Erbin knockout transgenic mice compared with that in the control mice (Fig. 4a, e). Here, ERBIN is linked to colorectal carcinoma.