Some evidences showed that PD1 or PDL1 on B cells can be immunomodulated in some tumors, such as breast cancer, liver cancer, colorectal cancer, and pancreatic cancer.45 The use of PD1 or PDL1 antibodies will block the interaction between PDL1 on tumor cells and PD1 on T cells, and restore the antitumor activity of T cells.46 PDL1+ PC cells have been shown to have immunosuppressive properties in solid tumors in studies of prostate cancer and spontaneous liver cancer. Here, CD274 is linked to familial pancreatic carcinoma.