Moreover, we analyzed the expression of Erbin in tumor-associated stromal cells mostly lymphocytes in CRC patients with or without distant metastasis (cohort1 and cohort2, Supplementary Table S2a, b) and found Erbin+ lymphocytes were mainly concentrated in the Norm, partly aggregated in IM, and rarely appeared at CT of primary tumors (Supplementary Fig. S2a, b). The gene discussed is ERBIN; the disease is colorectal carcinoma.