To our surprise, detectable Shh was also present in plasma-derived exovesicles from CML-CP patients (CML-1, 3; Supplementary Fig. 9A), though Shh expression or signaling was not detectable in leukemic cells (Fig. 1A, B). The gene discussed is SHH; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.