We found that the mRNA levels of IFIT1 and IFIT3 were dramatically increased in the nonmetastatic HCC tissue samples and the metastatic HCC tissue samples compared with the para-carcinoma tissue samples, and increased in the metastatic HCC tissue samples compared with the nonmetastatic HCC tissue samples (Fig. 5A). The gene discussed is IFIT3; the disease is hepatocellular carcinoma.