GPX1 and metabolic dysfunction-associated steatohepatitis: Furthermore, Nrf2 plays a major role in ameliorating various oxidative stress-associated diseases and exerts significant function in the antioxidant system, a recent study demonstrated that adropin reduced liver injury in nonalcoholic steatohepatitis by upregulating the expression of glutamate-cysteine ligase catalytic subunit(GCLC), glutamate-cysteine ligase regulatory subunit(GCLM) and glutathione peroxidase 1(Gpx1), dependent on Nrf2 transcriptional activity and increasing GSH levels [51].