MME and heart failure: Therefore, use of a combined NEP inhibitor with an AT1R antagonist through Entresto was developed and found to reduce the relative risk of cardiovascular death or first hospitalization by 20% in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial (Packer et al., 2015).