Indeed, our analyses identified genes associated with hormone receptor-positive breast cancer (e.g. ESR1, IL6ST, CD36, GLUL, RASA1) in the networks from the patients with estrogen receptor positive, LumA breast cancer and genes associated with the basal-like subtype (e.g., EGFR, SOX4, AKT1 as well as high levels of HNRNPK) in the basal-like patients, underlining the biological relevance of the networks. The gene discussed is ESR1; the disease is breast cancer.