APAF1 and cancer: 6-gingerol through inhibition of IkBα, nuclear translocation of NF-kB, suppression of Inducible nitric oxide synthase (iNOS), release of cytochrome c, increased expression of Apoptotic protease activating factor 1(Apaf-1), activation of caspase, stimulation of oxidative stress, induction of DNA damage, autophagy and increased protein activity of p53 and p21, causes apoptosis and thus prevents cancer progression and tumor growth [10, 78–84].