Various pathways including p38 mitogen-activated protein kinase, extracellular signal-regulate kinase 1/2 and c-Jun N-terminal Kinase 1/2, phosphatidylinositol 3-kinase/Akt and cell cycle checkpoint proteins cdk1 and cyclin B and cdc25C are involved in cell death induced by 6-Shogaol in cancer cells [16, 89, 90]. Here, AKT1 is linked to cancer.