CCNB1 and Familial prostate cancer: Yan et al. demonstrated that this gene suppresses prostate cancer by inhibiting c-Met expression [50], Qi et al. reported that the GPX3 gene inhibits the invasion of hepatocellular carcinoma cells [52], while An et al. investigated the mechanism of the GPX3-gene-mediated inhibition of proliferation of lung cancer cells, and showed that this gene inactivates ROS, thereby inhibiting the ERK–NF-κB–cyclin B1 signaling pathways and leading to cell-cycle arrest to cancer inhibition [53].