Forming of transgenic animals with overexpression or down-regulation of SIRT1 and SIRT2 proteins for tumorigenesis evaluation, research of the influence of other targets of SIRT1 and SIRT2 such as different doses or durations of radiations on interactions among SIRT1/SIRT2 and p53 in human cancers could be other targets. The gene discussed is TP53; the disease is cancer.