Importantly, we found that cofilin-actin rods induced by Aβd/t also occurs via a maraviroc/AMD3100-sensitive pathway implicating a contribution of CCR5 and CXCR4 chemokine receptors in AD, which we previously showed involves a PrPC/NOX-dependent signaling pathway [19]. The gene discussed is CFL1; the disease is Alzheimer disease.