We infected WT and Ifnar1-/-Ifngr1-/- mice, due to mouse availability, with CW3 or CW3I514F, and found that while CW3 infection led to dramatic weight loss of Ifnar1-/-Ifngr1-/- mice by 3 dpi, CW3I514F did not cause the same rapid morbidity (Fig 5B). Here, IFNGR1 is linked to infection.