Analysis of stool, ileum, colon, MLN, and spleen viral levels in survivors at 14 dpi demonstrated equivalent viral levels in Pou2f3+/-Stat1-/- and Pou2f3-/-Stat1-/- (Fig 6C and 6D), supporting that CR6F514I infection of intestinal and extraintestinal tissues of Stat1-/- mice is tuft cell-independent. Here, POU2F3 is linked to infection.