STAT1 and infection: We additionally infected Pou2f3+/-Stat1-/- and Pou2f3-/-Stat1-/- with MNoV strain WU23 containing L514, and found that while lethality was delayed in Pou2f3-/-Stat1-/- mice compared to Pou2f3+/-Stat1-/- littermates, all mice succumbed to infection (Fig 6E).