CCN4 and neoplasm: Moreover, WISP-1 appears to be responsible for mediating the Notch1-induced anti-tumor growth and anti-angiogenic effect of MAFs, as we previously demonstrated that attenuation of Notch1-upregulated WISP-1 expression by WISP-1-shRNA in fibroblasts could significantly liberate the inhibitory effect of N1IC-engineered stromal fibroblasts on tumor growth and angiogenesis in mouse model [11].