Diabetes mellitus (DM) is a chronic metabolic disease associated with major morbidity and mortality DM can be classified as type 1 diabetes (T1DM) when the pancreas fails to produce sufficient insulin due to autoimmune beta-cell destruction and type 2 diabetes (T2DM) when there is insufficient production of insulin and/or insulin resistance. The gene discussed is INS; the disease is type 1 diabetes mellitus.