MAN2A2 and liver disorder: Although the low minor allele frequency of the remaining 6 nsSNV associated with increased liver fibrosis (i.e., CCR7 rs2228015, GLT8D2 rs17035120, MAN2A2 rs52828316, MBL2 rs1800450, MCOLN2 rs77452813, and TGFB1 rs1800472) precluded detailed modeling, their previous associations with liver disease, metabolism, and viral immunity in other literature provide impetus for further investigation.