To address whether PKCδ is activated by misfolded SOD1 proteins, and since the phosphorylation of PKCδ-505T is necessary for its kinase activity [40], we analyzed the phosphorylation of PKCδ-505T in the spinal cords of transgenic mice expressing various ALS-linked SOD1 mutants. Here, SOD1 is linked to amyotrophic lateral sclerosis.