Besides, we propose a potential mechanism of the neuroprotective effect of casticin as an inhibitor of the activity of the TLR4/NF‐κB signaling pathway, inhibition of the expression of inflammatory factors TNF‐α, TGF‐β, IL‐6, and IL‐1β, and thus weaken the inflammatory response after cerebral ischemia, leading to a reduction in neuronal apoptosis. This evidence concerns the gene TNF and Cerebral ischemia.