CD274 and neoplasm: In anogenital SCC, advanced age, higher tumor grade and lymph node metastaseswere related to PD-L1 positive expression (OR = 1.63, 95% CI:1.04–2.58; OR = 2.49, 95% CI: 1.39–4.46; OR= 1.85, 95% CI: 1.28–2.66) (Table 2), demonstrated by the meta-analysis.