Conclusions: The meta-analysis demonstrated thatin anogenital SCC, PD-L1 positivity had to do with a worse outcome, which mightattribute to advanced age, higher tumor grade, lymph node metastasis and HPVnegativity, while in oropharynx cancer, PD-L1 expression was related to betterprognosis for the reason that PD-L1 was less frequent in the aged and negativeHPV status. The gene discussed is CD274; the disease is oropharynx cancer.