TNF and cancer: In an NOD/SCID/Il2rg null (NSG) xenograft animal model employing Human pancreas adenocarcinoma ascites metastasis (AsPC-1) cells, Authors demonstrated that cancers treated with the combination of the virus expressing TNF-α and IL-2 (Ad5/3-E2F-d24-TNF-α-IRES-IL-2 [OAd-TNFα-IL2]) along with CAR-T cells resulted in considerably greater accumulation of CAR-T cells at the tumor site, as well as augmented cancer regression [173].