In the same way, the increased sensitivity of C3H/HeJ mice to severe arthritis caused by live M. arthritidis is associated with type 1 cytokine profile, whereas, BALB/c mice (TLR4+) display a type 2 cytokine profile in response to MAM and develop a mild arthritis caused by M. arthritidis [289,296], indicating that MAM differentially regulates the cytokine response by unique interaction with TLRs, and this interaction may be associated with the severity of disease induced by M. arthritidis. This evidence concerns the gene TLR4 and Arthritis.