For example, limonene decreased the level of TNF‐α, IL‐1β, and IL‐6 and the expression of iNOS and COX‐2 in RAW 264.7 macrophage cells (Yoon et al., 2010); α‐pinene exerted antioxidant activities through restoring the activity of superoxide dismutase (SOD), CAT and GSH‐PX, and reducing the concentration of MDA, NO, and IL‐6 in ischemic brain tissue of rats (Khoshnazar et al., 2019); BEO prevented accumulation of intracellular ROS, reduced cell death of human neuroblastoma induced by excessive stimulation of the NMDA (Corasaniti et al., 2007). This evidence concerns the gene IL6 and neuroblastoma.