The Somogyi effect, also known as the ‘chronic Somogyi rebound’ or ‘post hypoglycemic hyperglycemia’, was described that when blood glucose levels dropped too low during the late evening, activation of counter‐regulatory hormones such as adrenaline, corticosteroids, growth hormone and glucagon might be observed, leading to activation of gluconeogenesis and resultant hyperglycaemia in the early morning.16 The gene discussed is GCG; the disease is Hyperglycemia.