This age-dependent partitioning of parkin was not seen for any other protein examined, including two other PD-linked proteins, i.e., DJ-1 and α-synuclein (Fig. 1a, f), or for organelle-associated markers, e.g., cytosolic glyoxalase-1, peroxiredoxin-1 and -3; and endoplasmic reticulum-associated calnexin. This evidence concerns the gene PRKN and Parkinson disease.