In parallels with neonatal diabetes, alteration in Katp channel function also plays an etiological role in the development of type 2 diabetes with the E23K/S1119 KCNJ11/ABCC8 variants associated with a 1.32 increase in the risk of type 2 diabetes (12). The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.