Taken together, our results suggest that, depending on the variable observed in the behavioural test, several genetic interactions occur to build the link of behavioural phenotyping outcome in DS mouse models with loci, spread along Mmu16, including Dyrk1a. With 1 h of retention time, the NOR test pointed only to Dyrk1a overexpression, with at least one suppressing loci in the Dp1Rhr trisomic region. Here, DYRK1A is linked to Dravet syndrome.