The t-SNE analysis, based on all the 4328 DEGs detected in each mouse model added together, showed different contributions of the various DS models to the transcriptome variation (Fig. 2B, left) with two distinct groups: one encompassing four overlapping trisomies: Ts65Dn, Dp5/Dp1, Dp5, Dp1Rh and three isolated models: Dp1Yey, Dp3Yah and Tg(Dyrk1a) that were closer together, although Dp3Yah was clearly farthest from the other two. Here, HRK is linked to Dravet syndrome.