HRK and Dravet syndrome: Using qRT-PCR, we confirmed the mRNA overexpression of first, Dyrk1a and Sod1 genes in the DS models where they were trisomic; second, of Synaptojanin2 (Synj2) and T lymphoma invasion and metastasis inducing gene 2 (Tiam2) located on the Mmu17 centromeric region in Ts65Dn, and third, of Cholinergic Receptor Nicotinic Alpha 1 Subunit (Chrna1), a gene misregulated in the Dp1Yey, Dp5/Dp1, Dp1Rhr and Ts65Dn models (Supplementary Material, Fig. S15), and Cbs downregulated in all the models except Tg(Dyrk1a) and Dp3Yah.