To improve our knowledge of DS, we analysed seven DS mouse models that carry either a large segmental duplication, like Dp1Yey, or a transgenic line overexpressing Dyrk1a, the main driver gene of the phenotype in mouse DS models, found on Mmu16 (24–28), and specific combinations of models (see Fig. 1A). Here, DYRK1A is linked to Dravet syndrome.