ERCC2 and xeroderma pigmentosum group D: The nucleotide excision repair (NER) pathway, a highly powerful and sophisticated DNA damage removal pathway, has been believed to play important roles in cancer progression and response to platinum-based chemotherapy.3, 4Excision repair cross-complementation groups 2 (ERCC2) are gene encoding one of the key enzymes in NER pathway.5ERCC2gene, also called the xeroderma pigmentosum group D (XPD) gene, is located at chromosome 19q13.3.